Chimeric serine proteases

US6159722A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfram Bode · Gauting, DE
• Richard Engh · Weßling, DE
• Karl-Peter Hopfner · Starnberg, DE
• Robert Huber · Midland, US
• Erhard Kopetzki · Penzberg, DE

Key dates

• Filing date: Nov 23, 1998
• Grant date: Dec 12, 2000
• Expiry date: Nov 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a .beta.-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half corresponds to the second domain half of a second serine protease, has improved properties and can be readily crystallized.