Method of treatment or inhibition of tumors using pyridyl-substituted metal-diphosphine complexes
US6159957A · kind A · utility
2Cited by
1References
5Claims
0Family size
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Key dates
| Filing date | Aug 18, 1999 |
| Grant date | Dec 12, 2000 |
| Priority date | — |
| Expiry date | Aug 18, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/12444
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treatment or inhibition of tumors involves administering a compound to a subject. The compound is one in which one or more of the eight phenyl substituents in the compound [M(dppe).sub.2 ].sup.+, in which M is selected from Au(I), Ag(I) and Cu(I), is substituted by 2, 3, or 4 pyridyl substituents. The compound has anti-tumor activity and an octanol/water partition coefficient between 0.01 and 25.5. The compound has selective toxicity to cancer cells, including cisplatin resistant human carcinoma cells lines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.