3-substituted pyrido [3',4':4,5] Thieno [2,3-d] pyrimidine derivatives, and production and use of the same

US6159981A · kind A · utility

Assignee

• BASF SE

Inventors

• Gerd Steiner · Tauberbischofsheim, DE
• Uta Dullweber · Bischofswerda, DE
• Dorothea Starck · Ludwigshafen, DE
• Alfred Bach · Heidelberg, DE
• Karsten Wicke · Ludwigshafen, DE
• Hans-Jurgen Teschendorf · Dudenhofen, DE
• Francisco Javier Garcia-Ladona · Kandel, DE
• Franz Emling · Ludwigshafen, DE

Key dates

• Filing date: Dec 8, 1999
• Grant date: Dec 12, 2000
• Expiry date: Dec 8, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-Substituted 3,4,5,6,7,8-hexahydropyrido [3',4':4,5]-thieno[2,3-d]pyrimidine derivatives of the formula I ##STR1## where R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.4 -alkyl group, an acetyl group, a phenylalkyl C.sub.1 -C.sub.4 radical, the aromatic system being unsubstituted or substituted by halogen, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, cyano or nitro groups, or is a phenylalkanone radical, it being possible for the phenyl group to be substituted by halogen, PA1 R.sup.2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which can be unsubstituted or mono- or disubstituted by halogen atoms, C.sub.1 -C.sub.4 -alkyl, hydroxyl, trifluoromethyl, C.sub.1 -C.sub.4 -alkoxy, amino, cyano or nitro groups and may contain 1 nitrogen atom, or to a 5- or 6-membered ring which may contain 1-2 oxygen atoms, PA1 A is NH or an oxygen atom, PA1 Y is CH.sub.2, CH.sub.2 --CH.sub.2, CH.…