6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit
US6160006A · kind A · utility
9Cited by
0References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 16, 1997 |
| Grant date | Dec 12, 2000 |
| Priority date | — |
| Expiry date | Oct 16, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity and in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. The present invention provides 6',7'-dihydroxybergamottin, a furanocoumarin, as the compound primarily responsible for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The present invention also provides a novel synthesis scheme for 6',7'-dihydroxybergamottin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.