Method for control of functionality during cross-linking of hemoglobins
US6160098A · kind A · utility
6Cited by
17References
21Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 29, 1998 |
| Grant date | Dec 12, 2000 |
| Priority date | — |
| Expiry date | May 29, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to cross-linked hemoglobins, and particularly to methods of controlling the functionality of such hemoglobins. The controlled functionalities include the P.sub.50 and the Hill coefficient. The present invention provides methods for producing a cross-linked hemoglobin with specific final functionalities by regulating the amount of both total hemoglobin and R-state hemoglobin prior to cross-linking, and by modulating cross-linking reaction conditions such as time, temperature, pH and the ratio of cross-linking reagent to hemoglobin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.