Patent · US Expired

Process for preparing N-[5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin -2-yl]-N-methylmethanesulfonamide

US6160115A · kind A · utility

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16Claims

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Assignee

LONZA LTD · CH

Inventors

Walter Brieden · Glis, CH
Ulrich Veith · Visp, CH

Key dates

Filing date	Mar 9, 2000
Grant date	Dec 12, 2000
Priority date	—
Expiry date	Mar 9, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/6512
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2- yl]-N-methylmethanesulfonamide of the formula: ##STR1## is prepared by reaction of [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidi n-5-yl]methanol with chlorodiphenylphosphine. Compound I is an intermediate in the synthesis of pharmaceutically active compounds, in particular HMG--Co A. reductase inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.