Per(poly)fluorinated polyoxyethylated carbamates

US6160161A · kind A · utility

Assignee

• F2 Chemicals Limited · GB

Inventors

• Hedi Trabelsi · Nice, FR
• Wolfgang Roehlke · Ulm, DE
• Peter Reuter · Bad Dürkheim, DE
• Massimo Napoli · Padova, IT
• Philippe Lucas · Nice, FR
• Kenneth Charles Lowe · Nottingham, GB
• Giampaolo Gambaretto · Padova, IT
• Ralf-Peter Franke · Blaustein, DE
• Carl Martin Edwards · Nottingham, GB
• Lino Conte · Padova, IT
• Aime Cambon · Nice, FR

Key dates

• Filing date: Dec 23, 1998
• Grant date: Dec 12, 2000
• Expiry date: Dec 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09K23/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Per(poly)fluorinated polyoxyethylated carbamates of general formula (I) in which R.sub.F represents a perfluorinated group containing between 1 and 18 carbon atoms, W represents an oxo group or nothing, n is an integer from 1 to 10, m is from values 2 to 6, 80 or not defined, R is an alkyl group, R.sub.F W(CH.sub.2).sub.n+1 NHC(O)-- in which R.sub.F and W are as defined above, --(CHCH.sub.3 CH.sub.2 O).sub.30 (CH.sub.2 CH.sub.2).sub.80 C(O)NH(CH.sub.2).sub.n+1 R.sub.F in which R.sub.F is a perfluorinated group containing from 1 to 18 carbon atoms, R' is a hydrogen atom, an alkyl group containing between 1 and 18 carbon atoms which is optionally substituted, an optionally substituted aryl or aralkyl group, an allyl, methallyl or propargyl group or a perfluorinated chain having between 1 and 18 carbon atoms. These compounds can be used as anti-thrombosis agents or as surfactants or cosurfactants for phospholipids intended for the preparation or stabilization of fluorocarbon emulsions, notably emulsions for biomedical applications.