Method for preparation of disodium pamidronate
US6160165A · kind A · utility
1Cited by
25References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 10, 1998 |
| Grant date | Dec 12, 2000 |
| Priority date | — |
| Expiry date | Dec 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/3873
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention includes a method for the preparation of disodium pamidronate comprising: (a) preparing a stirred slurry of pamidronate in water, (b) adding a solution of sodium hydroxide to give a clear solution at pH of about 6.5, (c) filtering the solution and (d) freezing and lyophilizing the solution to give an amorphous essentially anhydrous disodium pamidronate which contains .ltoreq.2 wt-% water.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.