Preparation of 6 hydroxy-7-deoxytaxanes using nocardioides luteus
US6162622A · kind A · utility
1Cited by
3References
8Claims
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Key dates
| Filing date | Jan 14, 1999 |
| Grant date | Dec 19, 2000 |
| Priority date | — |
| Expiry date | Jan 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6-.alpha.-hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.