Fluorinated xanthene derivatives
US6162931A · kind A · utility
145Cited by
24References
107Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1996 |
| Grant date | Dec 19, 2000 |
| Priority date | — |
| Expiry date | Apr 12, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S430/126
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.