Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
US6162949A · kind A · utility
5Cited by
3References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 22, 1999 |
| Grant date | Dec 19, 2000 |
| Priority date | — |
| Expiry date | Feb 22, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid loss.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.