Homogeneous human papillomavirus capsomere containing compositions, methods for manufacture, and use thereof as diagnostic, prophylactic or therapeutic agents

US6165471A · kind A · utility

Assignees

• University of Colorado, University Technology Corporation · US
• MedImmune Limited · US
• University of Rochester, Office of Research and Project Administration and Institute of Higher Education · US

Inventors

• Robert Garcea · Boulder, US
• JoAnn Suzich · Gaithersburg, US
• Michael McCarthy · Old Fort, US
• Robert C. Rose · Apache Junction, US

Key dates

• Filing date: Jul 2, 1998
• Grant date: Dec 26, 2000
• Expiry date: Jul 2, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/928
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.