Erythropoietin-mediated neurogenesis
US6165783A · kind A · utility
56Cited by
1References
12Claims
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Key dates
| Filing date | Oct 20, 1998 |
| Grant date | Dec 26, 2000 |
| Priority date | — |
| Expiry date | Oct 20, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are described for the production of neurons or neuronal progenitor cells. Multipotent neural stem cells are proliferated in the presence of growth factors and erythropoietin which induces the generation of neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin.
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