Isozyme-specific activators of protein kinase C methods and compositions
US6165977A · kind A · utility
142Cited by
5References
27Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 17, 1997 |
| Grant date | Dec 26, 2000 |
| Priority date | — |
| Expiry date | Oct 17, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Isozyme-specific agonists or activators of .epsilon.PKC are disclosed. The agonists include peptides corresponding to the region of .epsilon.PKC between about amino acids 85 and 92. Also disclosed are therapeutic methods employing such .epsilon.PKC-specific agonists to induce preconditioning and thereby reduce injury due to subsequent ischemia, as well as methods for screening test compounds for .epsilon.PKC-selective agonist properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.