2R, 4S, R, S- and 2S, 4R, R, S-hydroxyitraconazole
US6166018A · kind A · utility
1Cited by
17References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1999 |
| Grant date | Dec 26, 2000 |
| Priority date | — |
| Expiry date | Jun 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.