Antiestrogens, process for their production and their pharmaceutical use

US6166075A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ulrich Klar · Berlin, DE
• Rolf Bohlmann · Berlin, DE
• Karsten Parczyk · Berlin, DE
• Karl-Heinrich Fritzemeier · Berlin, DE
• Monika Lessl · Berlin, DE
• Rosemarie Lichtner · Berlin, DE

Key dates

• Filing date: Jun 9, 1999
• Grant date: Dec 26, 2000
• Expiry date: Jun 9, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.