Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors

US6166082A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Harold C. Kluender · Madison, US
• Guenter Hans Herbert Heinz Benz · Velbert, DE
• David R. Brittelli · Branford, US
• William Bullock · Easton, US
• Kerry Combs · Wallingford, US
• Brian R. Dixon · Woodbridge, US
• Stephan Schneider · Wuppertal, DE
• Jill Wood · Hampton, US
• Michael C. VanZandt · Guilford, US
• Donald J. Wolanin · Orange, US
• Scott Wilhelm · Orange, US

Key dates

• Filing date: Apr 9, 1998
• Grant date: Dec 26, 2000
• Expiry date: Apr 9, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/47
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula EQU (T).sub.x A--B--D--E--G wherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR1## the group E represents a three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents --M, ##STR2## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; and PA1 R.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof.