Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes

US6166200A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE

Key dates

• Filing date: Jul 2, 1999
• Grant date: Dec 26, 2000
• Expiry date: Jul 2, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cascade polymer complexes that contain PA1 a) complexing ligands of general formula I EQU A--{X--[Y--(Z--W--K.sub.W .sub.z).sub.y ].sub.x}.sub.a (I), in which PA2 A stands for a nitrogen-containing cascade nucleus of base multiplicity a, PA2 X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, PA2 Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, PA2 K stands for the radical of a complexing agent, PA2 a stands for numbers 2 to 12, PA2 x, y, z and w, independently of one another, stand for numbers 1 to 4, PA2 provides that at least two reproduction units are different and that for the product of the multiplicities, EQU 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true, PA1 b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, PA1 c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as PA1 d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.