Preparation of (S)-2-amino-6, 6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
US6166227A · kind A · utility
4Cited by
8References
8Claims
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Key dates
| Filing date | Jul 8, 1999 |
| Grant date | Dec 26, 2000 |
| Priority date | — |
| Expiry date | Jul 8, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The glycinamide of the formula (I) ##STR1## is reacted with the dioxolane of the formula (II) ##STR2## wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) ##STR3## Treatment of (III) gives the dioxolane pentanoic acid IV ##STR4## which can be converted to (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.