Methods for making modified recombinant vesiculoviruses
US6168943A · kind A · utility
48Cited by
4References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 3, 1996 |
| Grant date | Jan 2, 2001 |
| Priority date | — |
| Expiry date | May 3, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable vesiculoviruses, as well as recombinant replicable vesiculoviruses, from cloned DNA, by a method comprising expression of the full-length positive-strand vesiculovirus antigenomic RNA in host cells. The recombinant vesiculoviruses do not cause serious pathology in humans, can be obtained in high titers, and have use as vaccines. The recombinant vesiculoviruses can also be inactivated for use as killed vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.