Cyclic adhesion inhibitors

US6169072A · kind A · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Brunhilde Felding-Habermann · Village of La Jolla, US
• Friedrich Rippmann · Heidelberg, DE
• Beate Diefenbach · Darmstadt, DE
• Horst Kessler · Schwalbach, DE
• Roland Haubner · Garching bei München, DE
• Jochen Wermuth · Garching bei München, DE

Key dates

• Filing date: Oct 1, 1998
• Grant date: Jan 2, 2001
• Expiry date: Oct 1, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel cyclopeptides of the formula I EQU cyclo-(Arg-B-Asp-D-E) I in which B, D, and E have the meanings defined herein, and their salts. These compounds act as interin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.