Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function
US6169073A · kind A · utility
48Cited by
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13Claims
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Key dates
| Filing date | Feb 16, 1995 |
| Grant date | Jan 2, 2001 |
| Priority date | — |
| Expiry date | Feb 16, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.