Indolinones having kinase inhibitory activity

US6169106A · kind A · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Armin Heckel · Biberach an der Riß, DE
• Rainer Walter · Biberach, DE
• Wolfgang Grell · Biberach, DE
• Jacobus C. A. van Meel · Mittelbiberach, DE
• Norbert Redemann · Biberach, DE

Key dates

• Filing date: Apr 6, 1999
• Grant date: Jan 2, 2001
• Expiry date: Apr 6, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted indolinones of general formula ##STR1## wherein R.sub.1 to R.sub.5, and X are defined as in claim 1, the isomers thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibitory effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these (compounds, their use and processes for preparing them.