Method for targeting in vivo nitric oxide release
US6171232A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1997 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | Jun 26, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/901
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The preparation and use of medical devices are described. A thiol group agent is loaded onto a medical device such as a stent or a catheter. Preferably, the loading is accomplished onto a polymeric surface that had been activated by water vapor RF plasma treatment. The thiol group agent is structured to exhibit sulfhydryl groups. These sulfhydryl groups are available for interaction with NO carriers such as nitrovasodilators. This interaction can take place in situ at an in vivo location within a vascular system, for example, in which event the sulfhydryl groups would be delivered by the medical device while the NO carrier will be delivered by suitable pharmaceutical administration means. Alternatively, the NO carrier can be loaded onto the treated medical device surface at a suitable time prior to insertion of the medical device into the body, such as immediately before the initiation of a medical procedure such as stent delivery and implantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.