Dopamine transporter imaging agent

US6171576A · kind A · utility

Assignees

• Organix, Inc. · US
• President and Fellows of Harvard College · US
• Massachusetts Institute of Technology · US

Inventors

• Peter Meltzer · Lexington, US
• Bertha K. Madras · Newton, US
• Alan Davison · Needham, US
• Paul Blundell · Winchester, US
• Ashfaq Mahmood · Newton, US
• Alun G. Jones · Newton, US

Key dates

• Filing date: Nov 3, 1995
• Grant date: Jan 9, 2001
• Expiry date: Nov 3, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.