Process for producing efonidipine hydrochloride preparations
US6171599A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 9, 1998 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | Sep 9, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/675
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amorphous solid dispersion of efonidipine hydrochloride having a high intestinal absorbability can be formed by subjecting a mixture containing efonidipine hydrochloride of the formula (I), hydroxypropylmethylcellulose acetate succinate and optionally a thermostabilizer to a step A of heat treatment at from 85 to 140.degree. C. or mechanochemical treatment at from 0 to 140.degree. C., and then to a step B of dipping treatment into a water-containing solution, impregnation treatment with a water-containing solution or contacting treatment with a water vapor-containing gas; or treating the above-mentioned mixture with a hot steam at from 100 to 140.degree. C. and a high pressure. Further, in the above-mentioned step A, the mixture is subjected to high frequency heating, making it possible to give a solid dispersion of efonidipine hydrochloride having a high intestinal absorbability without using the step B. This process is quite advantageous in the production in that the use of an organic solvent is not required. Formula (I): ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.