Sustained release theophylline formulations, excipient systems and methods of production
US6171615A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 6, 1998 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | Jul 6, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/4866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A stable sustained release theophylline formulation is prepared by incorporating theophylline into a semi-solid matrix comprising polyglycolized glycerides (GELUCIRE.RTM. excipient) and a mixture of nucleation enhancers. Theophylline is admixed with molten GELUCIRE to make the sustained release formulation. The nucleation enhancer composition is then incorporated in the admixture to make the sustained release formulation resistant to changes in dissolution upon aging. Orally administrable compositions are prepared by filling gelatin capsules with the formulation. The polyglycolized glycerides (GELUCIRE) and the nucleation enhancer composition also can be used as an excipient system for preparing sustained release pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.