Methods of controlling beta dimer formation in hemoglobin
US6171826A · kind A · utility
1Cited by
4References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 1999 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | May 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/805
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to methods of controlling beta dimer formation in hemoglobin solutions by altering the metal binding site adjacent to the N-terminus of beta globins. The invention further relates to methods of producing stable, intramolecularly crosslinked beta globins by exposure to Ni(II) and oxone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.