Luminescence indicator for determining calcium ions

US6171866A · kind A · utility

Assignee

• AVL Medical Instruments · CH

Inventors

• Huarui He · Alpharetta, US
• Mark Mortellaro · Woodstock, US

Key dates

• Filing date: Sep 30, 1998
• Grant date: Jan 9, 2001
• Expiry date: Sep 30, 2018

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/64
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to a compound having the general Formula I: ##STR1## including its salts, where Z is either the group having the general Formula II: ##STR2## where PA1 R.sub.1 is alkyl having 1-4 C atoms, alkoxyalkyl having 2-5 C atoms or aryloxyalkyl whose alkyl group has 1-4 C atoms, PA1 R.sub.2 is alkyl having 1-4 C atoms or alkoxyalkyl having 2-5 C atoms, PA1 R.sub.3 is H, alkoxy having 1-4 C atoms, halogen, NO or NO.sub.2, PA1 Y is H.sub.2 or O and PA1 L is a luminophoric moiety in a position para or meta to the nitrogen, PA1 or is the group having the general Formula III: ##STR3## where PA1 n is 2 or 3, PA1 R.sub.4 is alkyl having 1-4 C atoms or alkoxyalkyl having 2-5 C atoms, PA1 R.sub.5 is H, alkoxy having 1-4 C atoms, halogen, NO or NO.sub.2 and PA1 L is a luminophoric moiety in a position para or meta to the nitrogen, PA1 or is the group having the general Formula IV: ##STR4## where PA1 R.sub.6 is alkyl having 1-3 C atoms or phenyl, PA1 R.sub.7 is H, alkoxy having 1-4 C atoms, halogen, NO or NO.sub.2 and PA1 L is a luminophoric moiety in a position para or meta to the nitrogen. The compound of the invention can be used as a luminescence indicator for the determinati…