2-substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists
US6172067A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1999 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | Aug 5, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is unsubstituted, mono-, di- or tri-substituted (C.sub.3 -C.sub.11)cycloalkyl or (C.sub.3 -C.sub.11)cycloalkenyl or the like, A is unsubstituted (C.sub.1 -C.sub.7)alkyl or (C.sub.2 -C.sub.5 )alkenyl, or unsubstituted, mono-, di- or tri-substituted aryl, or aromatic-heterocyclic or the like, Y is hydrogen, halo, amino or mercapto, or unsubstituted, mono-, di- or tri- substituted (C.sub.1 -C.sub.10)alkyl-M--, (C.sub.3 -C.sub.7)cycloalkyl-M--, (C.sub.2 -C.sub.6)alkenyl-M--, (C.sub.1 -C.sub.4)alkyl-NH-((C.sub.1 -C.sub.4)alkyl)-M--, di(C.sub.1 -C.sub.4)alkyl-N-((C.sub.1 -C.sub.4)alkyl)-M--, aryl-M--, aromatic or non-aromatic heterocyclic-M--, aryl-(C.sub.1 -C.sub.5)alkyl-M-- or aromatic non-aromatic heterocyclic-(C.sub.1 -C.sub.5)alkyl-M--, wherein M is a covalent bond O, S, NH or the like, or the like; Z.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 are hydrogen or the like, has ORL1-receptor agonist activity, and are useful as analgesics or the like in mammalian subjects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.