Method for synthesizing labelled compounds

US6172207A · kind A · utility

Assignees

• Coincidence S. A. · BE
• UNIVERSITÉ LIBRE DE BRUXELLES · BE
• UNIVERSITE DE LIEGE · BE

Inventors

• Philippe E. Damhaut · Chênée, BE
• Michel Monclus · Mons, BE
• John J. Van Namen · Geraardsbergen, BE
• Eric Mulleneers · Tubize, BE
• Jean-Luc Morelle · Liège, BE
• Christian Lemaire · Alleur, BE
• André Luxen · Ocquier, BE
• Benjamin P. Lauricella · Ans, BE

Key dates

• Filing date: Jul 29, 1998
• Grant date: Jan 9, 2001
• Expiry date: Jul 29, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process and a device for synthesizing labeled compounds. The process involves preparing a labeling agent, labeling a precursor with the labeling agent, where the precursor is a protected substrate, and deprotecting the labeled precursor to convert the labeled precursor to a labeled compound by passing the labeled precursor through a solid support in a column or a cartridge. The process may be used to convert labeled tetraacetylfluoroglucose (TAFg) to labeled fluoro-deoxy-glucose (FDG) for use in nuclear medical imaging. The process is more rapid than conventional methods and is performed at room temperature rather than high temperature for conventional technology.