Patent · US Expired

Oligonucleotides modified with conjugate groups

US6172208A · kind A · utility

119Cited by
1References
5Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJul 6, 1992
Grant dateJan 9, 2001
Priority date—
Expiry dateJul 6, 2012

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q1/6876
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

An oligonucleotide wherein at least one nucleotide unit of the oligonucleotide is conjugated with a moiety selected from the group consisting of: (a) amino acids; (b) dipeptide mimics; (c) sugars; (d) sugar phosphates; (e) neurotransmitters; (f) poly-hydroxypropylmethacrylamide; (g) dextrans; (h) polymaleic anhydride; (i) cyclodextrins; (j) starches; and (k) polyethyleneimine. The oligonucleotides may be employed for binding to an RNA, and DNA, a protein, or a peptide to inhibit or prevent gene transcription or gene expression, to inhibit or stimulate the activities of target molecules, or the oligonucleotides may be employed as diagnostic probes for determining the presence of specific DNA or RNA sequences or proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.