Amphiphilic agents for membrane protein solubilization
US6172262A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 1999 |
| Grant date | Jan 9, 2001 |
| Priority date | — |
| Expiry date | Jan 27, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are amphiphilic compounds comprising Formula I: ##STR1## PA1 wherein R.sub.1, R.sub.2, and R.sub.3 are C.sub.2 -C.sub.12 straight or branched alkyl; unsubstituted phenyl, biphenyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.3 -C.sub.8 cycloalkenyl; or phenyl, biphenyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.3 -C.sub.8 cycloalkenyl substituted with one, two, or three C.sub.1 -C.sub.6 straight or branched alkyl groups; or R.sub.1 and R.sub.2 combined are C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.8 cycloalkenyl; or C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkenyl substituted with one, two, or three C.sub.1 -C.sub.6 straight or branched alkyl groups; one of R.sub.4 or R.sub.5 is selected from the group consisting of C.sub.2 -C.sub.6 -straight or branched alkyl-(dimethyl-N-oxide), alkyl-(dimethylamine), alkyl-(trimethylammonium), alkyl-glucosyl, alkyl-maltosyl, glucosyl, maltosyl, and polyethylene(glycosyl); the other of R.sub.4 or R.sub.5 is selected from the group consisting of H, C.sub.2 -C.sub.6 straight or branched alkyl or alkenyl, C.sub.2 -C.sub.6 -straight or branched alkyl-(dimethyl-N-oxide); alkyl-(dimethylamine), alkyl-(trimethylammonium), alkyl-glucosyl, al…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.