Biomatrix for soft tissue regeneration using mesenchymal stem cells
US6174333A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 29, 1998 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Dec 29, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2017/00004
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.