Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene
US6174674A · kind A · utility
18Cited by
3References
25Claims
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Key dates
| Filing date | Jun 19, 1998 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Jun 19, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded by the ALK (Anaplastic Lymphoma Kinase) gene is a membrane-spanning protein tyrosine kinase (PTK)/receptor. Antibodies to the ALK PTK/receptor and methods utilizing such antibodies are described, as are methods of using the ALK gene to isolate ligands for the ALK PTK/receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.