[6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin

US6174885A · kind A · utility

Assignee

• Shiseido Company, Limited · JP

Inventors

• Hirotada Fukunishi · Yokohama, JP
• Tsunao Magara · Tokyo, JP
• Koji Kobayashi · Yokohama, JP

Key dates

• Filing date: Feb 26, 1999
• Grant date: Jan 16, 2001
• Expiry date: Feb 26, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C.sub.10-30 expressed by R.sup.1 and the other is--(CH.sub.2)n-NR.sup.2 R.sup.3 ; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.2 and R.sup.3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; --NR.sup.5 --(CH.sub.2)n-NR.sup.2 R.sup.3 or --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 may be Group W, and --OCONR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 may be --OCO--W, wherein W is a formula of: ##STR2## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen, lower alkyl, phenyl or benzyl group; R.sup.4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R.sup.5 and R.sup.6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methy…