Amide compounds and use of the same
US6174887A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 1998 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Feb 20, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, hydroxy and the like, R.sup.5 is H, alkyl and the like, m is an integer of 0-6, R.sup.6 is an optionally substituted aryl and the like, and R.sup.7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-.alpha., GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.