Patent · US Expired

2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin -4-ones

US6174888A · kind A · utility

23Cited by

4References

9Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Leslie Wighton McQuire · Hackettstown, US
Benjamin Mugrage · Berkeley Heights, US
John H. van Duzer · Phillipsburg, US

Key dates

Filing date	May 28, 1998
Grant date	Jan 16, 2001
Priority date	—
Expiry date	May 28, 2018

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/519
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to the 2-amino-7-(1-substituted-2-hydroxyethyl)-3, 5-dihydro-pyrrolo[3,2-d] pyrimidin-4-ones of formula I ##STR1## and tautomers thereof, wherein Ar represents biaryl, carbocyclic or heterocyclic aryl; pharmaceutically acceptable prodrug ester derivatives; and pharmaceutically acceptable salts thereof, which are particularly useful as potent purine nucleoside phosphorylase (PNP) inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.