Method of inhibiting cytokine release from human ocular cells
US6174914A · kind A · utility
6Cited by
4References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 15, 1999 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Jun 15, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/335
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.