Human chemokines, CK.beta.4 and CK.beta.10/MCP-4

US6174995A · kind A · utility

Inventors

• Haodong Li · Gaithersburg, US
• Mark D. Adams · Potomac, US
• Solange Hanschke Lima · Silver Spring, US
• Ralph Alderson · Gaithersburg, US
• Yuling Li · Germantown, US
• David Parmelee · Rockville, US
• John R. White · Wadsworth, US
• Edward Applebaum · Blue Bell, US

Key dates

• Filing date: Feb 23, 1996
• Grant date: Jan 16, 2001
• Expiry date: Feb 23, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.