Processes and intermediates for the preparation of piperazine derivatives
US6175012A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1998 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Jan 22, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D419/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds having the formula EQU R.sup.5 O--A--NR.sup.4 --R.sup.2 (V) where R.sup.2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R.sup.4 and R.sup.5 are both hydrogen atoms or together represent --SO-- or --SO.sub.2 -- and A is C.sub.2 -C.sub.4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R.sup.4 and R.sup.5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI). EQU R.sup.2 O--A--NH.sub.2 (VI)
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.