Process for preparation of propionic acid derivatives
US6175018A · kind A · utility
0Cited by
1References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 1999 |
| Grant date | Jan 16, 2001 |
| Priority date | — |
| Expiry date | Mar 16, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/643
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
(R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II ##STR1## in an inert organic solvent, without isolation of the intermediate products, with M.sub.2 CO.sub.3, in which M is sodium or potassium, into the compound of formula III ##STR2## reacting this with the compound of formula IV ##STR3## to form the compound of formula V ##STR4## and converting this with a compound of formula VI ##STR5## wherein Z signifies phenylsulphonyl, tosyl, methylsulphonyl, nosyl, bromophenyl, Cl-, Br- or CICO-, into the compound of formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.