Recombinant host cells for the production of polyketides
US6177262A · kind A · utility
7Cited by
8References
13Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 28, 1998 |
| Grant date | Jan 23, 2001 |
| Priority date | — |
| Expiry date | Oct 28, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Yields of polyketides produced in host cells such as Streptomyces can be increased by coexpression of the ptpA gene. The introduction of recombinant vectors encoding ptpA and polyketide synthase genes is more efficient and does not require methyl-free DNA if the host cell is a restriction/methylation deficient strain, such as Streptomyces lividans K4-114, K4-155, or K27-39.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.