Deoxynojirimycin derivatives and their uses as glucosylceramidase inhibitors
US6177447A · kind A · utility
17Cited by
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7Claims
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Key dates
| Filing date | Apr 30, 1999 |
| Grant date | Jan 23, 2001 |
| Priority date | — |
| Expiry date | Apr 30, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/46
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Deoxynojirimycin derivatives containing a large hydrophobic moiety, such as cholesterol or adamantame-methanol, linked through a spacer, such as pentamethylene, to the nitrogen atom of deoxynojirimycin, and salts thereof, inhibit glucosylceramidase and may be useful in the treatment of diseases involving a ceramide-mediated signaling process, such as Gaucher disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.