Regulation of alzheimer's disease proteins and uses thereof
US6177472A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 27, 1998 |
| Grant date | Jan 23, 2001 |
| Priority date | — |
| Expiry date | Oct 27, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/138
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of regulating the assembly of the protein tau in the brain of a mammal in need of such treatment comprising the step of administering to said mammal a pharmacologically effective amount of a fatty acid liberation or release inhibitor. Also provided is a method of inhibiting production of Alzheimer-type amyloidosis in a mammal comprising the step of administering to said mammal in need of such treatment an effective amount of at least one modulator of fatty acid liberation or release, said modulator capable of controlling the rate of assembly of proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques. In another embodiment of the present invention, there is provided a method of stimulating polymerization of a tau protein, comprising the step of contacting said protein with a fatty acid. In another embodiment of the present invention, there is provided a method of stimulating polymerization of a amyloid peptide, comprising the step of contacting said peptide with a fatty acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.