NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same
US6180084A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 25, 1998 |
| Grant date | Jan 30, 2001 |
| Priority date | — |
| Expiry date | Aug 25, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/948
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method of identifying a tumor homing molecule that homes to angiogenic vasculature by contacting a substantially purified NGR receptor with one or more molecules and determining specific binding of a molecule to the NGR receptor, where the presence of specific binding identifies the molecule as a tumor homing molecule that homes to angiogenic vasculature. The invention also provides a method of directing a moiety to angiogenic vasculature in a subject by administering to the subject a conjugate including a moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor, whereby the moiety is directed to angiogenic vasculature. In addition, the invention provides a method of imaging the angiogenic vasculature of a tumor in a subject by administering to the subject a conjugate having a detectable moiety linked to a tumor homing molecule that exhibits specific binding to an NGR receptor and detecting the conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.