Enhanced ciruclation effector composition and method

US6180134A · kind A · utility

Assignee

• Sequus Pharmaceuticals, Inc. · US

Inventors

• Samuel Zalipsky · Redwood City, US
• Martin C. Woodle · Bethesda, US
• Francis J. Martin · San Francisco, US
• Yechezkel Barenholz · Jerusalem, IL

Key dates

• Filing date: Jun 7, 1995
• Grant date: Jan 30, 2001
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/812
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A liposome composition comprising small, surface-bound effector molecules is disclosed. The liposomes have a surface layer of hydrophilic polymer chains, for enhanced circulation time in the bloodstream. The effector molecules are attached to the distal ends of the polymer chains. In one embodiment, the effector is polymyxin B, for treatment of septic shock.