Method for preparing tert-leucine and analogues thereof in enantiomeric form and intermediates therein
US6180374A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1998 |
| Grant date | Jan 30, 2001 |
| Priority date | — |
| Expiry date | Aug 10, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/003
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Azlactone (3), or the opposite enantiomer thereof, undergoes biotransformation, using suitable enzymatic activity, in the presence of a compound YH to form a N-acyl-amino acid (2), wherein R.sup.1, R.sup.2 and R.sup.3 are each not hydrogen and are independently selected from groups containing up to 20 carbon atoms, optionally with any combination of R.sup.1, R.sup.2 and R.sup.3 being joined together to form at least one ring, X is selected from groups containing up to 20 carbon atoms, and Y is selected from the group consisting of --OH, -Oalkyl and -Nalkyl. Amino acid (1), or the opposite enantiomer thereof, can be prepared in high enantiomeric excess from N-acyl amino acid (2), by converting Y to OH. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.