Cyclin-selective ubiquitin carrier polypeptides

US6180379A · kind A · utility

Assignee

• Presidents and Fellows of Harvard University · US

Inventors

• Joan V. Ruderman · Wellesley, US
• Avram Hershko · Haifa, IL
• Marc W. Kirschner · Newton, US
• Fiona Townsley · Somerville, US
• Alexander Aristarkov · Boston, US
• Esther Eytan · Haifa, IL
• Hongtao Yu · Dalian, CN

Key dates

• Filing date: Mar 31, 1997
• Grant date: Jan 30, 2001
• Expiry date: Mar 31, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.