Virion-constrained nanoparticles comprising a plant virion coat protein shell and encapsulated guest molecules
US6180389A · kind A · utility
24Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1997 |
| Grant date | Jan 30, 2001 |
| Priority date | — |
| Expiry date | Jan 3, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A virion-constrained nanoparticle of the invention comprises a shell of a virion coat protein(s) that encapsulates a core non-viral material, which is organic, inorganic or organometallic in nature. A particularly preferred virion coat is that of cowpea chlorotic mottle virus (CCMV). Encapsulation of a desired particle is effected by adjusting reaction conditions, e.g., by lowering the pH of a solution containing the virion protein and the non-viral substance. Processes for producing the virion-constrained nanoparticles of the invention are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.